Biography of Norma McCorvey, Roe in Roe v. Wade

Biography of Norma McCorvey, 'Roe' in Roe v. Wade Norma McCorvey (September 22, 1947–February 18, 2017) was a young pregnant woman in Texas in 1970 without the means or funds to have an abortion. She became the plaintiff known as Jane Roe in Roe v. Wade, which was decided in 1973 and became one of the most famous Supreme Court decisions of the 20th century. McCorveys identity was hidden for another decade but, during the 1980s, the public learned about the plaintiff whose lawsuit struck down most abortion laws in the United States. In 1995, McCorvey made news again when she declared she had changed to a pro-life stance, with newfound Christian beliefs. Fast Facts: Norma McCorvey Known For: She was Roe in the famous Supreme Court abortion case Roe. v. Wade.Also Known As: Norma Leah Nelson, Jane RoeBorn: Sept. 22, 1947 in Simmesport, LouisianaParents: Mary and Olin NelsonDied: Feb. 18, 2017 in Katy, TexasPublished Works: I Am Roe (1994), Won by Love (1997)Spouse: Elwood McCorvey (m.  1963–1965)Children: Melissa (Nothing is publicly known of the two children McCorvey gave up for adoption.)Notable Quote: â€Å"I wasn’t the wrong person to become Jane Roe. I wasn’t the right person to become Jane Roe. I was just the person who became Jane Roe, of Roe v. Wade. And my life story, warts and all, was a little piece of history.† Early Years McCorvey was born on Sept. 22, 1947, as Norma Nelson to Mary and Olin Nelson. McCorvey ran away from home at one point and, after returning, was sent to reform school. After the family moved to Houston, her parents divorced when she was 13. McCorvey suffered abuse, met and married Elwood McCorvey at age 16, and left Texas for California. When she returned, pregnant and frightened, her mother took her baby to raise. McCorveys second child was raised by the father of the baby with no contact from her. McCorvey initially said that her third pregnancy, the one in question at the time of Roe v. Wade, was the result of rape, but years later she said she had invented the rape story in an attempt to make a stronger case for an abortion. The rape story was of little consequence to her lawyers because they wanted to establish a right to abortion for all women, not just those who had been raped. Roe v. Wade Roe v. Wade was filed in Texas in March 1970 on behalf of the named plaintiff and all women similarly situated, typical wording for a class-action lawsuit. Jane Roe was the lead plaintiff of the class. Because of the time it took for the case to make its way through the courts, the decision did not come in time for McCorvey to have an abortion. She gave birth to her child, whom she put up for adoption. Sarah Weddington and Linda Coffee were the Roe v. Wade plaintiffs lawyers. They were looking for a woman who wanted an abortion but did not have the means to obtain one. An adoption attorney introduced the lawyers to McCorvey. They needed a plaintiff who would remain pregnant without traveling to another state or country where abortion was legal because they feared that if their plaintiff obtained an abortion outside of Texas, her case could be rendered moot and dropped. At various times, McCorvey has clarified that she did not consider herself an unwilling participant in the Roe v. Wade lawsuit. However, she felt that feminist activists treated her with disdain because she was a poor, blue-collar, drug-abusing woman instead of a polished, educated feminist. Activist Work After McCorvey revealed that she was Jane Roe, she encountered harassment and violence. People in Texas yelled at her in grocery stores and shot at her house. She aligned herself with the pro-choice movement, even speaking at the U.S. Capitol in Washington, D.C., She worked at several clinics where abortions were provided. In 1994, she wrote a book, with a ghostwriter, called I am Roe: My Life, Roe v. Wade, and Freedom of Choice. The Conversion In 1995, McCorvey was working at a clinic in Dallas when Operation Rescue moved in next door. She allegedly struck up a friendship over cigarettes with Operation Rescue preacher Philip Flip Benham. McCorvey said that Benham talked to her regularly and was kind to her. She became friends with him, attended church, and was baptized. She surprised the world by appearing on national television to say that she now believed abortion was wrong. McCorvey had been in a lesbian relationship for years, but she eventually denounced lesbianism as well after her conversion to Christianity. Within a few years of her first book, McCorvey wrote a second book, Won by Love: Norma McCorvey, Jane Roe of Roe v. Wade, Speaks Out for the Unborn as She Shares Her New Conviction for Life. Later Years and Death In her later years, McCorvey was nearly homeless, relying on â€Å"free room and board from strangers, says Joshua Prager, who wrote an extensive story about her published in Vanity Fair in February 2013. McCorvey eventually ended up in an assisted-living facility in Katy, Texas, where she died of heart failure on Feb. 17, 2017, at age 69, according to Prager, who was working on a book about her at the time of her death. Legacy Since the Roe v. Wade ruling, about 50 million legal abortions have been performed in the United States, although later court decisions and new state and federal laws have imposed restrictions, and abortions have declined with the wide use of contraceptives, according to McCorveys obituary published in The New York Times. Many of those who oppose abortions have called the Roe v. Wade lawyers immoral, saying that they took advantage of McCorvey. In fact, if she had not been Roe, someone else would likely have been the plaintiff. Feminists across the nation were working for abortion rights at the time. Perhaps something McCorvey herself said in a 1989 New York Times article best sums up her legacy: More and more, Im the issue. I dont know if I should be the issue. Abortion is the issue. I never even had an abortion. Sources Hersher, Rebecca. â€Å"Norma McCorvey Of Roe v. Wade Embodied The Complexity Of American Abortion Debate.†Ã‚  NPR, 18 Feb. 2017.Langer, Emily. â€Å"Norma McCorvey, Jane Roe of Roe v. Wade Decision Legalizing Abortion Nationwide, Dies at 69.†Ã‚  The Washington Post, 18 Feb. 2017.McFadden, Robert. â€Å"Norma McCorvey, Roe in Roe v. Wade, Is Dead at 69.†Ã‚  The New York Times, 18 Feb. 2017Prager, Joshua. â€Å"Tracing the Life of Norma McCorvey, ‘Jane Roe’ of Roe v. Wade, and Why Shed Favor an Abortion Ban.†Ã‚  The Hive, Vanity Fair, 30 Jan. 2015.

An Overview of Christallers Central Place Theory

An Overview of Christallers Central Place Theory Central place theory is a spatial theory in urban geography that attempts to explain the reasons behind the distribution patterns, size, and a number of cities and towns around the world. It also attempts to provide a framework by which those areas can be studied both for historical reasons and for the locational patterns of areas today. Origin of the Theory The theory was first developed by the German geographer  Walter Christaller  in 1933 after he began to recognize the economic relationships between cities and their hinterlands (areas farther away). He mainly tested the theory in southern Germany and came to the conclusion that people gather together in cities to share goods and ideas and that communities- or central places- exist for purely economic reasons. Before testing his theory, however, Christaller had to first define the central place. In keeping with his economic focus, he decided that the central place exists primarily to provide goods and services to its surrounding population. The city is, in essence, a distribution center. Christallers Assumptions To focus on the economic aspects of his theory, Christaller had to create a set of assumptions. He decided that the countryside in the areas he was studying would be flat, so no barriers would exist to impede peoples movement across it. In addition, two assumptions were made about human behavior: Humans will always purchase goods from the closest place that offers them.Whenever the demand for a certain good is high, it will be offered in close proximity to the population. When demand drops, so too does the availability of the good. In addition, the threshold is an important concept in Christallers study. This is the minimum number of people needed for a central place business or activity to remain active and prosperous. This led to Christallers idea of low- and high-order goods. Low-order goods are things that are replenished frequently such as food and other routine household items. Since people buy these items regularly, small businesses in small towns can survive because people will buy frequently at closer locations instead of going into the city. High-order goods, by contrast, are specialized items such as automobiles, furniture, fine jewelry, and household appliances that people buy less often. Because they require a large threshold and people do not purchase them regularly, many businesses selling these items cannot survive in areas where the population is small. Therefore, these businesses often locate in big cities that can serve a large population in the surrounding hinterland. Size and Spacing Within the central place system, there are five sizes of communities:   HamletVillageTownCityRegional capital A hamlet is the smallest place, a rural community that is too small to be considered a village. Cape Dorset (population 1,200), located in Canadas Nunavut Territory is an example of a hamlet. Examples of regional capitals- which are not necessarily political capitals- would include Paris or Los Angeles. These cities provide the highest order of goods possible and serve a huge hinterland. Geometry and Ordering The central place is located at the vertexes (points) of equilateral triangles. Central places serve the evenly distributed consumers who are closest to the central place. As the vertexes connect, they form a series of hexagons- the traditional shape of many central place models. The hexagon is ideal because it allows the triangles formed by the central place vertexes to connect, and it represents the assumption that consumers will visit the closest place offering the goods they need. In addition, central place theory has three orders or principles. The first is the marketing principle and is shown as K3 (where K is a constant). In this system, market areas at a certain level of the central place hierarchy are three times larger than the next lowest one. The different levels then follow a progression of threes, meaning that as you move through the order of places, the number of the next level increases threefold. For example, when there are two cities, there would be six towns, 18 villages, and 54 hamlets. There is also the transportation principle (K4) where areas in the central place hierarchy are four times bigger than the area in the next lowest order. Finally, the administrative principle (K7) is the last system where the variation between the lowest and highest orders increase by a factor of seven. Here, the highest order trade area completely covers that of the lowest order, meaning that the market serves a larger area. Losch’s Central Place Theory In 1954, German economist August Losch modified Christallers central place theory because he believed it was too rigid. He thought that Christallers model led to patterns where the distribution of goods and the accumulation of profits were based entirely on location. He instead focused on maximizing consumer welfare and creating an ideal consumer landscape where the need to travel for any good was minimized, and profits remained relatively equal, regardless of the location where goods are sold. Central Place Theory Today Though Loschs central place theory looks at the ideal environment for the consumer, both his and Christallers ideas are essential to studying the location of retail in urban areas today. Often, small hamlets in rural areas do act as the central place for various small settlements because they are where people travel to buy their everyday goods. However, when they need to buy higher-value goods such as cars and computers, consumers who live in hamlets or villages have to travel into the larger town or city, which serves not only their small settlement but those around them as well. This model is shown all over the world, from rural areas of England to the U.S. Midwest or Alaska with the many small communities that are served by larger towns, cities, and regional capitals.

Current Elections Assignment Example | Topics and Well Written Essays - 250 words

Current Elections - Assignment Example Watching Romney’s speech (2012) focused on making him more appealing to the public and showing the softer side to him. Talks about his wife and how they had struggled to raise their children made him more â€Å"human†. At the Democrats’ convention, Barack Obama promised to reduce the national deficit and to reform the tax codes so that the wealthiest people would be the ones to pay the highest taxes. Obama also promised to end the Afghanistan war by 2014, and to reduce the cost of healthcare. However, in as much as Obama outlined energy, education, the national deficit, manufacturing, and national security as his goals if re-elected, he failed to specify how he would achieve such goals. Nevertheless, Obama made it clear that the process required a lot of sacrifices and that total reform was going to take â€Å"more than a few years† (President Barack Obama Full DNC Acceptance Speech, 2012). Between the two acceptance speeches, Obama’s carried more weight, as he made it about the people and not about himself. Obama was clearer about where he would invest money and made it clear that the middle class would not have to carry the burden of the national deficit. Although Romney sold himself as a family man and someone with more â€Å"experience†, judging by the content of their acceptance speeches, Obama would be the ideal candidate to lead America for the next four years. Furthermore, Obama’s acceptance speech has more likes than

Metropolitan Police in Security Essay Example | Topics and Well Written Essays - 1500 words

Metropolitan Police in Security - Essay Example The Metropolitan police service has several identities linked to their current jobs. The identities include the amount of confidential data used, bunches, the emails and other police based identities. Therefore there is need to embrace modern technologies which will see them satisfy their requirements (CONANT & MOLZ, 2002). The requirement includes proper authorization of documents and information and adequate authentication of all information used in daily activities. Fuel-based authentication of the document will ensure that all information within the websites or Occurrence Book can be accessed countrywide from a single source. This means that different authorities can rely on single source security center for information. Currently, the modern technologies, which can be relied on, include. RSA based authentication Management system where authentication based software is used by the police unit to manage all security-based tokens, users, applications and multiple resources. The sys tem has instrumentally helped in managing authentically based policies for the whole police unit. The system can also help the Metropolitan Police Service unit to meet flexibility, scalability and high level of efficiency. In most companies and especially the security-based organization such as G4S, the system has been found to be highly secure in protecting encryption of the information collected about cases and criminals. In addition to that, it has been argued that it is highly effective given that it applies the Novell based electronic directory. Moreover, it has been recently improved to have the Oracle directory services.

Literacy Narrative Essay Example for Free

Literacy Narrative Essay Due Date: Friday night, September 6th by midnight in the digital dropbox on Angel Desired Learning Outcomes: 1.Understand our personal development as readers and writers or persons 2.Explore writing as a means of self-discovery 3.Choose the appropriate voice, diction, and audience for a personal literacy narrative 4.Use various invention, drafting and revising/editing strategies as needed 5.Demonstrate appropriate conventions of grammar and style of written English 6.Use technology effectively and correctly to complete the assignment READINGS FOR PAPER: 1.Norton, Chapter 7: Writing a Literacy Narrative, Chapter 40: Narrating, and Chapter 57: additional examples of literacy narratives to be selected by the instructor 2. Quick Access Concise, Chapter 1: Understanding College and Other Writing Situations and Chapter 7a c: Strategies for Writing Typical Kinds of College Papers ASSIGNMENT: After completing the readings for this assignment, follow the guidelines in Chapter 7 of your Norton Field Guide, particularly pages 43-46. Additional tips on the writing process itself appear in the chapter, as well as samples from professional writers. As your text advises, follow these steps. 1.Choose a topic. A single event that you recall vividly would be a good choice. See the suggestions on page 43. 2.Consider the rhetorical situation, particularly your audience and stance. Your instructor will discuss conventions in more detail, but this type of writing does not require a formal tone and may use the first person (â€Å"I†). Grammar and  format, however, need to be correct. 3.Be sure you understand the nature of narrating (Chapter 40) and have the kinds of details and stance that motivate and excite your readers. A good narrative always has an element of conflict. 4.Apply the information in your Field Guide on generating ideas, drafting, and revising under the direction of your instructor.

Its Time for Voluntary Euthanasia and Assisted Suicide :: Euthanasia Physician Assisted Suicide

America Needs Voluntary Euthanasia      Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   There are at least two forms of suicide. One is 'emotional suicide', or irrational self-murder in all of it complexities and sadness. Let me emphasis at once that my view of this tragic form of self-destruction is the same as that of the suicide intervention movement and the rest of society, which is to prevent it wherever possible. I do not support any form of suicide for mental health or emotional reasons.      Ã‚  Ã‚  Ã‚   But I do say that there is a second form of suicide -- justifiable suicide, that is, rational and planned self-deliverance from a painful and hopeless disease which will shortly end in death. I don't think the word 'suicide' sits well in this context but we are stuck with it. Many have tried to popularize the term 'self-deliverance' but it is an uphill battle because the news media is in love with the words 'assisted suicide'. Also, we have to face the fact that the law calls all forms of self-destruction 'suicide.'      Ã‚  Ã‚  Ã‚   Let me point out here for those who might not know it that suicide is no longer a crime anywhere in the English-speaking world. (It used to be, and was punishable by giving all the dead person's money and goods to the government.) Attempted suicide is no longer a crime, although under health laws a person can in most states be forcibly placed in a psychiatric hospital for three days for evaluation.      Ã‚  Ã‚  Ã‚   But giving assistance in suicide remains a crime, except in the Netherlands in recent times under certain conditions, and it has never been a crime in Switzerland, Germany, Norway and Uruguay. The rest of the world punishes assistance in suicide for both the mentally ill and the terminally ill, although the state of Oregon recently (Nov. l994) passed by ballot Measure 16 a limited physician-assisted suicide law. At present (Feb. l995) this is held up in the law courts.      Ã‚  Ã‚  Ã‚   Even if a hopelessly ill person is requesting assistance in dying for the most compassionate reasons, and the helper is acting from the most noble of motives, it remains a crime in the Anglo-American world. Punishments range from fines to fourteen years in prison. It is this catch- all prohibition which I and others wish to change.

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Huntington’s disease is an autosomal dominant (Harper et al, 1991) neurodegenerative disorder characterized by involuntary movements, cognitive loss, and psychiatric problems as described by Martin and Gusella (1986). These symptoms are related to the death of medium spiny projection neurons in the caudate nucleus, putamen, and the cortex (Reiner et al, 1988). In later stages of the disease, even areas such as the hippocampus and hypothalamus gets affected as well (Kassubek et al, 2004). Huntington’s disease has a prevalence rate of approximately 1 in 10,000 Caucasian populations (Harper et al, 1991).Patients with Huntington’s disease most typically display a choreic movement disorder involving involuntary writhing movements observed by George Huntington himself. The age of onset of Huntington’s disease seem to be normally distributed around the average age of 35 to 42, with small number of cases developing in patients younger than 20 years of age or older than 60 years of age (Andrew et al, 1993). The majority of juvenile patients, whose disease onset are at age 20 years or less, have inherited the paternally defected gene (Andrew et al, 1993).Patients usually died within 15 to 20 years of disease onset. Gusella et al (1983) first determined the location of the genetic mutation in Huntington’s disease to be the short arm of chromosome 4. It was after another 10 years did the researchers of The Huntington’s Disease Collaborative Research Group (1993) able to discover that a gene in chromosome 4 containing a trinucleotide repeat of CAG was abnormally expanded in diseased individuals. The IT15 (interesting transcript 15) gene, dubbed the huntingtin gene by the group, codes for the huntingtin gene.This CAG repeat, which translates into a poly-glutamine stretch, is highly polymorphic among the population ranging from 11 to 34 copies on normal individuals. However, in individuals with Huntington’s disease it expanded to more than 42 repeats and increasing to upwards of 100 (The Huntington’s Disease Collaborative Research Group, 1993). This provides evidence showing that the mutant huntingtin protein seems to be toxic to its native cells and confers a disease state to individuals with an extended length of repeats. There is also a correlation between the CAG length and disease onset as shown by Andrew et al (1993).The mutated elongated huntingtin protein is cut by enzymes into fragments and the fragments begin to form abnormal clusters, neuronal intranuclear inclusions (NIIs), inside cells. These clusters can also act to recruit normal proteins to adhere together as well (Davies et al, 1997). This was originally thought to cause the pathogenesis of Huntington’s disease. However, more recent studies have shown that the presence of NIIs is actually a coping response to the toxicity of mutant huntingtin proteins and acts to prolong the life of the cells and reduce intracellular mutant huntingtin in neighbouring neurons (Arrasate et al, 2004).The exact function of the wild-type huntingtin protein are unclear, however many efforts have been made in understanding its native functions. Nasir et al (1995) showed that homozygous huntingtin homologs in mice died before embryogenesis could occur and that heterozygotes displayed similar deficits as diseased human patients. Wild-type huntingtin is also crucial for establishing and maintaining neuronal identity, especially in cortex and striatum (Reiner et al, 2001).Current data can provide the conclusion that normal huntingtin protein has actions important for development in mammals. In vitro, wild-type huntingtin have been shown to act to protect brain cells from apoptotic stimuli, such as serum deprivation, mitochondrial toxins, or the transfection of death genes (Cattaneo et al, 2005). Wild-type huntingtin protein, not mutated, stimulates brain-derived neurotrophic factor (BDNF) production by acting at level of Bdnf tra nscription. BDNF is very important for survival of striatal neurons (Cattaneo et al, 2005).Intracellularly, huntingtin protein has been found to associate with various organelles such as the nucleus, endoplasmic reticulum, and Golgi complex (Cattaneo et al, 2005). It has also been found in neurites and at synapses, where it associates with vesicular structures and microtubules (Li et al, 2003). This characteristic has been shown to enhance vesicular transport of BDNF along microtubules (Gauthier et al, 2004). On a similar note, huntingtin interacts with a number of cytoskeletal and synaptic vesicle proteins that are essential for exo- and endocytosis at synaptic terminals.Wild-type huntingtin binds directly to the Src homology 3 domain of postsynaptic density protein 95, which binds NMDA and kainite receptors. This activity is decreased in mutant proteins and can lead to overactivation or sensitization of NMDA receptors (Cattaneo et al, 2005). Aside from the toxicity of the mutated huntingtin protein, the loss of normal huntingtin protein also seems to add to the pathogenesis of Huntington’s disease. Presence of only mutant huntingtin protein results in massive apoptotic cell death in the testes of male mice (Leavitt, 2001).However, no apoptosis can be seen in testes of mice expressing human mutant huntingtin when wild-type huntingtin is expressed as well (Leavitt, 2001). It was also seen that in mice, the absence of wild-type huntingtin protein led to a worsening of striatal atrophy and neuronal loss, and a significant decrease in neuronal cross-sectional area compared to mice that had wild-type huntingtin present (Cattaneo et al, 2005). Huntington’s disease still remains incurable to this day. However, many treatments are available for treatments of its symptoms.Chorea, the hallmark of the disease is a major target for many treatments. Such drugs include dopamine-depleting agents, dopamine antagonists, benzodiazepines, glutamate antagonists, ac etylcholinesterase inhibitors, dopamine agonists, antiseizure medications, cannabinoids, lithium, deep brain stimulation and fetal cell transplantation (Frank and Jankovic, 2010). One notable drug currently in use is Tetrabenazine, which is the only US FDA-approved drug for treatment of Huntington’s disease (Frank and Jankovic, 2010).The drug acts by reversibly inhibiting the central vesicular monoamine transporter type 2, this cause a depletion of dopamine (Bagchi, 1983). The main area of effect for tetrabenazine is in the caudate nucleus, putamen, and the nucleus accumbens, all areas known to be responsible for the major pathology of the disease. The Huntington Study Group (2006) was able to demonstrate the efficacy of tetrabenazine in a double-blind, placebo-controlled trial. Subjects who received tetrabenazine showed a change from the baseline in the maximal chorea score of the UHDRS.Compared to the baseline, treatment resulted in a reduction of 5. 0 units in chorea compa red with a 1. 5 unit reduction for the placebo group. A second symptom targeted for treatment to allow patients to function normally is the psychiatric problems. Dopamine receptor blocking agents are commonly used as anti-psychotics in order to treat psychosis associated with Huntington’s disease (Frank and Jankovic, 2010). There are many ethical issues that have been associated with Huntington’s disease patients, in particular pertaining to the application of genetic testing.The expanded CAG repeats associated with Huntington’s disease (Gusella et al, 1983) are used as a predictive testing to determine the risk of a person for developing inherited HD gene. The debate of ethics with respect to genetic testing for Huntington’s disease seems to lie on several major factors including: autonomy, beneficence, confidentiality, and justice (Huggins et al, 1990). The question remains whether or not the current use of genetic predictive testing is ethical. Autonom y refers to the respect for the individual’s right to make an informed decision about an action that may have a profound effect on his or her life.The patients should feel no pressure from physicians or institutions with regards to their decision for genetic testing. Also, they should also have a full understanding of the consequences and implications of their decisions. This would require physicians to provide all the necessary information to the patients so that they are informed about the testing. If a woman refuses to get tests done for her baby even though her relatives are with her insisting on getting it performed, the physician cannot allow the testing to be performed.Beneficience is summarized by the phrase â€Å"first do no harm† (Huggins et al, 1990). This is an important factor when the results of the test may reveal genetic information about oneself. This implies not only avoiding harm to patient but also preventing harm to other individuals, which may inc lude family members of patients. Due to the genetic characteristics of Huntington’s disease, family members can be both directly and indirection influenced by the results of the test.If for example a pregnant woman decides to get an ultra sound for her baby in order to find out if the baby has spina bifida, and upon confirmation by the physician decides that she wants to give birth at home as opposed to in a hospital where the baby could be treated correctly in order to minimize the risk of the disease. The physician should take any action he can in order to avoid any risk to the health of the baby. Confidentiality with genetic tests applies the same as with any other form of personal information. It should not be disclosed to any other third parties, which includes family members as well.For example, if two siblings were to go and receive a CAG repeat test at the same time and one sibling asks the physician about the results of the other sibling. The physician cannot disclos e any information or they will violate the confidentiality of the patient. Justice simply means equal access to health services and information to all. This also includes long-term support and guidelines for testing as a medical service so that the service is not difficult to obtain if needed. For example, even though Cystic Fibrosis is mostly only prominent in Caucasians, the testing should still be offered to regnant women of other ethnicities as well. Other ethical dilemmas still exist with current genetic testing technologies. One particularly pertaining to Huntington’s disease is whether or not the information is obtained even though there is no cure for the disease. In diseases such as phenylketonuria (PKU), after newborn screening, dietary interventions will allow the individuals with the condition to lead healthy and normal lives (Lea et al, 2005). However, for Huntington’s disease, even after knowing that the disease will affect the individual what can be done ?Therefore, would it be better to not know at all? By testing and finding out that an individual has the mutation that will eventually lead to the development of Huntington’s disease, the individual can attend to the initial development of symptoms and as a result may be treated much earlier. This can result in a more favourable prognosis. Similarly, the individual can live more cautiously as to prevent further exacerbation of their condition. On a more subjective level, the individual may use the knowledge to live a more fulfilling life knowing that he or she may not live as long as the rest of the population.Conversely, the information can also be used negatively. There can be a lot of discrimination in terms of applying for employment and health insurance. This information would also impact the ambition and life goals of the individual, the amount of psychological harm that comes with eventually developing an incurable and lethal neurodegenerative disease is extremely larg e. Similarly, would they still pursue to have a family and children if they knew that they had a very high risk of dying at a young age? This particular issue should be resolved by following the ethical factors listed before.As long as the individual is informed, are being prevented from harm, information not shared with any third party members, and has access to healthcare services, then being tested for Huntington’s disease will be ethically correct. This knowledge will give them insight on how to live the rest of their life. Another dilemma that has Harper, P. S. , Morris, M. J. , Quarrell, O. , Shaw, D. J. , Tyler, A. , and Youngman, S. (1991). The epidemiology of Huntington’s disease. J. Med. Genet. 89: 365-376. Martin, J. B. , and Gusella, J. K. (1986).Huntington’s disease: pathogenesis and management. N. Engl. J. Med. 315: 1267-1276. Andrew, S. E. , Goldberg, Y. P. , Kremer, B. , Telenius, H. , Theilmann, J. , Adamn, S. , Starr, E. , Squitieri, F. , Lin, B. , Kalchman, M. A. , Graham, R. K. , and Hayden, M. R. (1993). The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington’s disease. Nat Genet. 4: 398-403. The Huntington’s Disease Collaborative Research Group (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes.Cell. 72: 971-983. Gusella, J. F. , Wexler, N. S. , Coneally, P. M. , Naylor, S. L. , Anderson, M. A. , Tanzi, R. E. , Watkins, P. C. , Ottina, K. , Wallace, M. R. , Sakaguchi, Y. A. , et al. (1983). A polymorphic DNA marker genetically linked to Huntington’s disease. Nature. 306: 234-238. Reiner, A. , Albin, R. L. , Anderson, K. D. , D’Amato, C. J. , Penney, J. B. , and Young, A. B. (1988). Differential loss of striatal projection neurons in Huntington disease. Proc. Natl Acad. Sci. USA. 85: 5733–5737. Kassubek, J. , Gaus, W. , and Landwehrmeyer, G. B. (2004).Evidence for more w idespread cerebral pathology in early HD: and MRI-based morphometric analysis. Neurology. 62: 523-524. Nasir, J. , Floresco, S. B. , O’Kusky, J. R. , Diewert, V. M. , Richman, J. M. , Zeisler, J. , Borowski, A. , Marth, J. D. , Philips, A. G. , and Hayden, M. R. (1995). Targeted disruption of the Huntington’s disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell. 81: 811-823. Cattaneo, E. , Zuccato, C. , and Tartari, M. (2005). Normal huntingtin function: alternative approach to Huntington’s disease.Nat Rev Neurosci. 6: 919-930. Li, J. Y. , Plomann, M. & Brundin, P. (2003). Huntington’s disease: a synaptopathy? Trends Mol. Med. 9: 414–420. Reiner, A. , Del Mar, N. , Meade, C. A. , Yang, H. , Dragatsis, I. , Zeitlin, S. , and Goldowitz, D. (2001). Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice. J. Neurosci. 21: 7608-7619. Gauthier, L. R. , Charrin, B. C. , B orrell-Pages, M. , Dompierre, J. P. , Rangone, H. , Cordelieres, F. P. , De Mey, J. , MacDonald, M. E. , Lessmann, V. , Humbert, S. , and Saudou, F. 2004). Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell. 118: 127-138. Leavitt, B. R. , Guttman, J. A. , Hodgson, J. G. , Kimel, G. H. , Singaraja, R. , Vogl, A. W. , and Hayden, M. R. (2001). Wild-type hungtingtin reduces the cellular toxicity of mutant huntingtin in vivo. Am. J. Hum. 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Literature Review †Organisational Change Essay

Team report you are to list 6 issues facing CanGo that you gleaned from the week 1 and 2 videos. They should be prioritized in order of importance. They should be numbered. The team must then come up with an actionable recommendation for each of the issues found. These should also be numbered. 1. CanGo does not have a a concise vision or mission statement that defines who they are as a company. Solution: CanGo needs to find out what market they want to be in and also figure out what market they want to be in, and where they see themselves going as a company and what values they have. . CanGo did not approach the strategic planning correctly for the online gaming. They discussed going into a new market with no prior knowledge of how the market operates. They also do not have the proper staff to begin the new business venture. Solution: I think that CanGo should do more research for the online gaming market. I also think that if they decide to go in this new direction that they should outsource some of the work and train some of the people they have on hand to help save costs. Liz needs to sit down and complete all of he steps in the strategic management process, including: SWOT analysis, mission statement, long term goals, implementation, strategic choice, evaluation, revision, and vision statement. Conducting a firm financial analysis of the overall project can prevent and reduce higher costs. Setting short-term and long-term goals will give the team a better outlook on the launch of the online gaming system. 3. Nick’s issue with organization is indicative of a bigger issue; the company does not have a structured approach to scheduling, planning, or reporting progress. Solution: CanGo lacks organization. There should be a better system for filing information, and a clear understanding of what each individual’s responsibilities within the company are. This way they would have a better understanding of which staff members are capable to complete which jobs, and those which be able able to with more training. This way tasks will not be inappropriately assigned. Set up a training session or a number of sessions as needed to bring everyone up to speed as far as what is expected for status reporting, prioritizing, scheduling tasks, and de-conflicting schedules. . Nick and the team members are not organized and they are distracting to each other when they are supposed to be working. Solution: The members should be more considerate in talking about some other topics. They can talk about side topics after work, and not during meetings. The main focus is to help out Nick on how to be successful on their new venture. Nick needs to be organized and read y to do the job. 5. Nick did not have a proper plan in place for the launch of the gaming system. He also did not step up and ask for help when he needed it. Solution: Nick should have figured at a proper plan for the launch of the online gaming system. A strategic goal plan should have been approved and put in place before Nick and the team were able to start on the project . Nick should have prioritized and been specific about the goals in the planning of the project through the use of the Gantt Chart. This would have allowed him to give a breakdown of all the issues that needed to be addresses such as hardware, software, recommendations, price comparisons, and testing. Nick not only failed to ask for help, but he did not ask any clarifying questions when the project was assigned to him. The instructions he was proved when given the project were vague and incomplete. He should have advised someone if he was incapable of doing the job in the first place, but he also should have sought more information and assistance if he was capable of doing the job. 6. During the planning meeting the manager quickly points out issues and made statements such as, â€Å"we need†, â€Å"we should†. He never gave any specific assignments, no dates or expectations. Solution: Design a structure for meetings such as this. Have the manager come into the meeting with a determined list which everyone can add to and discuss. He should also assign people to specific tasks based on their skills along with an expected completion date to make certain nothing is dropped. Establishing the projected deadline and developing an outline of the tasks to be accomplished over the course of time will help him reach his goals.

Themes and Ideas in The Merchants Tale Essay Example

Themes and Ideas in The Merchants Tale Essay Example Themes and Ideas in The Merchants Tale Essay Themes and Ideas in The Merchants Tale Essay The imagery in the general prologue tells Chaucers audience the Merchant is skilled and wise full well his wit bisette and Chaucers use of language like forked berd and in mottelee not only portrays the Merchant in a precise way, but ensures that the readers think and feel the same way about the Merchant as Chaucer. In The Merchants Tale Chaucer concerns himself with many themes, amongst which are marriage, honesty, religion and women. The opening of the tale explores the Merchants negative outlook on marriage and how bitterly he feels towards his wife I have a wyf, the worst that may be. The initial impression given to the reader is that Chaucer believes marriage is mainly a man letting himself in for a life time of weeping and wailing and Chaucer makes certain to the reader that if he had the chance to marry again, he wouldnt. Chaucer makes it very clear to the reader he is anti-feminist and implies he can tell more sorrow than a stabbed bachelor, due to his unhappiness throughout marriage. The Merchant claims talking about myn owene soore, is too upsetting, so continues to tell a story of a worthy knight.. a wyflees man was he. This worthy knight, aged sixty begins to feel the desire for a wife however before this age was used to doing what he wanted with women, folwed ay his bodily delit and thinking nothing more of it. The knight would try day and night to dooth al that he kan to find a woman as he believed no other life is worth a bene;. The irony presented here is that the Merchant feels negatively about marriage yet is explaining how ultimately even the most sexually orientated of bachelors will eventually seek this sacrament. Issues raised in the opening to the tale, when discussing marriage is if the knight suddenly realising he should get a wife, whether this be for security as hes reaching old age, or if it be for religious reasons. Religion is another theme Chaucer uses tastefully in the opening of the tale as man and womman, a biblical reference to Adam and Eve is mentioned and marriage is compared to paradis, the garden of Eden. Although this image of marriage being wonderful is being spoken by the knight, Chaucer is telling it through the Merchant. The confusing and interesting nature of this is that in the general prologue the Merchant doesnt have a good word to say about marriage, but hes telling this tale of a knight that was desperate to take a yong wif and live a life of joye and solas, therefore implying marriage is not so bad. In lines 99 to 103, the Merchant compares Gods gift of a wife, to material possessions. The detailed nature of these lines wyf is Goddes yifte .. as londes, rentes, pasture or commune shows how the Merchant, through the Knight explains the value of a wife is similar to that of the value of material goods such as land and furnishings. The story of creation in Genesis not only explains Gods creation of a woman to keep Adam company, but shows the how a woman caused the downfall of mankind, by being tempted to eat the forbidden fruit in the Garden of Eden. This is a story Chaucers target audience would we have been aware of. The Merchant shows the Knight being fond of marriage, but at the same time is taking a dig at women for causing the downfall of mankind, and implying this is what will happen if the Knight marries. A brief reference to anti-feminist literature writer Theofrast, by the knight reassures readers that he understands what hes taking onboard when seeking a wife. What force though Theofraste liste lye? .. a trewe servant dooth moore diligence claims Theofrast, but the knight, knowing Theofrast thinks a servent would be more faithful than a waife, still stays keen on the idea of marriage and we know this by the reference to the wedding vows keep him, sik and hool him to love and serve till he sterve he regards marriage as important, and is being slightly feminist as hes reassuring the audience that a woman will always stick by her man, as she swears to it on their wedding day. Ultimately, Chaucer explores a variety of themes and issues in the opening of the Merchants tale, and although he approaches marriage negatively, he seems to contradict himself when telling the story about the knight. Nevertheless, due to the general prologue and Chaucers description of the Merchant with forked berd shows him as a shady character, so however Chaucer seems to be portraying this knight, we know its likely to change as the tale continues.

How Sentence Combining Works

How Sentence Combining Works An alternative to traditional forms of grammar instruction, sentence combining gives students practice in manipulating a variety of basic sentence structures. Despite appearances, the goal of sentence combining is not to produce longer sentences but rather to develop more effective sentences  - and to help students become more versatile writers. How Sentence Combining Works Heres a simple example of how sentence combining works. Consider these three short sentences: The dancer was not tall.The dancer was not slender.The dancer was extremely elegant. By cutting out the needless repetition and adding a few conjunctions, we can combine these three short sentences into a single, more coherent sentence. We might write this, for instance: The dancer was not tall or slender, but she was extremely elegant. Or this: The dancer was neither tall nor slender but extremely elegant. Or even this: Neither tall nor slender, the dancer was extremely elegant nonetheless. Which version is grammatically correct? All three of them. Then which version is most effective? Now thats the right question. And the answer depends on several factors, beginning with the context in which the sentence appears. The Rise, Fall, and Return of Sentence Combining As a method of teaching writing, sentence combining grew out of studies in transformational-generative grammar and was popularized in the 1970s by researchers and teachers such as Frank OHare  and William Strong. Around the same time, interest in sentence combining was heightened by other emerging sentence-level pedagogies, especially the generative rhetoric of the sentence advocated by Francis and Bonniejean Christensen. In recent years, after a period of neglect (a period when researchers, as Robert J. Connors has noted, did not like or trust exercises of any kind), sentence combining has made a comeback in many composition classrooms. Whereas in the 1980s, as Connors says, it was no longer enough to report that sentence-combining worked if no one could specify why it worked, research has now caught up with practice: [T]he preponderance of writing instruction research shows that systematic practice in combining and expanding sentences may increase students repertoire of syntactic structures and may also improve the quality of their sentences, when stylistic effects are discussed as well. Thus, sentence combining and expansion are viewed as a primary (and accepted) writing instructional approach, one that has emerged from research findings holding that a sentence combining approach is far superior to traditional grammar instruction.(Carolyn Carter, The Absolute Minimum Any Educator Should Know Teach Students About the Sentence, iUniverse, 2003)

MBA - Corporate Finance - Capital Budgeting - 6 question Essay

MBA - Corporate Finance - Capital Budgeting - 6 question - Essay Example c. Mutual exclusivity requires a business organization to choose only one project. Consistent with the goal of every company to maximize its wealth, the project with the higher NPV is chosen regardless of the investment cost. Thus, project B is chosen over project A even though its IRR and MIRR is lower. Since the lowest even life cycle of the projects under consideration is 12, the Equivalent Annual Annuity is utilized in order to make the best decision. Thus, the present values of cash flows within the first three years of each project are computed. Afterwards, these are divided by the PVIFA of the projects. For project A, this means dividing it with the PVIFA within 3 years at 8% while for project B a life of 4 years and 8% discount rate is utilized. At the end, the four year alternative is chosen because it has a higher NPV of ($63,100.92). a. Any investment should still be evaluated regardless of the fact that the investment is higher than the cash inflow. It should be noted that the profitability of an investment is not solely based on whether the investment exceeds the cash inflow because of the time value of money. Evaluation of the project using different required rates of return also reveals that NPVs can be positive or negative depending on the discount rate. b. For this project, there are two computed IRRs which is due to the fact that there is a change in the sign of cash flow for the project’s life span. For the first year, there is an outflow (negative cash flow) while in the second year cash flow is positive. During the end of its life, the project again has a negative cash flow. Since, the sign changes twice, two IRRs are expected. As computed by Excel, these IRRs are 10.09% and 20.81% indicating that NPVs are zero in these discount rates. c. Figure 1 in the Appendix shows the computed NPVs at discount rates of 5% (NPV=-$730.16) , 15% (NPV=$215.50), 18% (NPV=$159.44) and 25%

Context paper English 105 Essay Example | Topics and Well Written Essays - 500 words

Context paper English 105 - Essay Example Ryves Hall has proved to be a second home for children of all ages in the Terre Haute locality, regardless of race or money. They serve children from ages three to seventeen and all their programs are age related, appropriately designed to benefit the children. Ryves Hall has been offering service to any children who walk in. All the activities provided by the institutions are free for the children. Their primary mission is to assist children and families in Terra haute, which is one of the most impoverished areas in the locality. They serve children who lack educational facilities, unemployment, hunger and poverty. It is the beacon of hope for many young Americans who are deprived of basic necessities in life. Most of the children who attended Ryves can be put under â€Å"at- risk youth â€Å"as they come from single parent, below poverty line and children who do not have anyone to turn to. â€Å"Students from lower socio-economic status are often denied the same luxuries that other students take for granted. These individuals often live in a single parent homes where the mother is the sole financial provider, disciplinarian and caregiver and may face issues such as hunger, live infestations, lack of hot water and inadequate attention† (Miller). Ryves Hall takes care of these children who lack the normal home upbringing. The children who are under their wings are between three and seventeen. Half of them come from minority population. Their main aim is to give them a second chance in life and to bring them up in the best possible way. Living in a home where basic needs as well as guidance are not available can have a negative impact on the children. Ryes Hall acts as their mentor and guides them to be respectable citizens in the society. Most of the children in Ryes Hall display problems associated with having to grow up too early due to lack of proper guidance at home. Many of them have experienced substance abuse, physical abuse, sexual abuse and low